Postdoc in gene-editing of iPSC-derived cardiomyocytes (SFU)
Earliest Start Date: May 1, 2018
Postdoctoral position – Gene-editing of iPSC-derived cardiomyocytes to study ion channelopathies
T Claydon lab, Simon Fraser University (Vancouver)
PROJECT SUMMARY:
A postdoctoral position is available in the lab of Tom Claydon in the Molecular Cardiac Physiology Group at SFU in Vancouver, Canada (http://www.sfu.ca/mcpg/members/tom-claydon.html). Our research focuses on the physiology, pharmacology and biophysics of cardiac ion channels, particularly K+ channels, such as hERG.
We use an array of techniques and models including optical mapping of ex vivo hearts, conventional and fluorescence-coupled electrophysiology (e.g. patch clamp, TEVC, VCF, LRET), molecular modelling, proteomics, CRISPR, iPSC-derived cardiomyocytes, zebrafish hearts, heterologous expression systems (e.g. HEK, Xenopus). Our goal is to better understand channel function and regulation to discover novel therapeutic targets and mechanisms for the treatment and management of Long QT syndrome (LQTS).
POSITION SUMMARY:
This position is for a highly motivated, detail-oriented and collaborative applicant who will generate gene-edited (using CRISPR-Cas9) isogenic or patient-specific iPSC-derived cardiomyocytes and perform functional and pharmacological assessment of these cell lines using optical mapping and/or electrophysiology.
TO APPLY, PLEASE FORWARD THE FOLLOWING TO thomas_claydon@sfu.ca:
• Cover letter
• Curriculum vitae
• Names and contact details for three referees
| REQUIRED QUALIFICATIONS: | Postdoctoral fellows and PhD students in the final stages of their degree are encouraged to apply. |
| PREFERRED EXPERTISE: | Prior experience with cell culture and molecular biological techniques is preferred. Expertise in electrophysiology is also of value. |
| APPOINTMENT DETAILS: | The position is available from May 1, 2018. Applicants will be reviewed immediately and until the position is filled. Salary will be funded through recently awarded CIHR grant funds and will be commensurate with qualifications and experience. The typical salary range will be $40,000 to $50,000 per year. |